Three cities – Lyon, Munich, Vienna – will be SMARTER TOGETHER

In September 2015, the cities of Lyon, Munich and Vienna and 28 partners from research and industry were awarded funding for a joint project proposal within the European „Smart City and Communities“ intiative. Under the headline „SMARTER TOGETHER“, the consortium applied for a volume of 25 Mio. EUR for the implementation of „smart“ and innovative actions in the three partner cities and for cooperation with three so called follower cities – Santiago de Compostela, Sofia und Venice. The requested funding is available as part of the EU-framework programme for research and innovation „Horizon 2020“. The funding is provided to support the implementation and testing of innovative Smart City solutions for low energy districts on a large scale and in an integrated way: Extensive energetic renewal of existing housing stock with (in Lyon and Munich) multi-faceted ownership structures, user-centered sustainable mobility solutions, innovative business models, generation of renewable energy and multiple use of infrastructure through the use of information- and communication technology (ICT). The overall aim is to improve the quality of life in neighbourhoods and to create more sustainable and user-friendly living environments. A particular focus will be on „smart“ and active forms of participation of citizens. The timeframe for the project roll-out is three years (2016-2018) followed by two years of monitoring and evaluation (2019-2020). Thereafter, successful solutions and findings are to be replicated in other districts and cities for further added value. Here, the follower cities Santiago de Compostela, Sofia and Venice as well as the European city network Energy Cities will play an important role. The projects will be implemented in close cooperation between industry, small and medium-sized enterprises, municipal companies, citizens and other interested stakeholders. The EU commission lauded the right balance between innovative technologies and the social dimension of the project: smart and integrated solutions shall improve the quality of life of citizens. The main challenge of Smarter Together is related to the so-called co-creation approach. All involved cities, research institutes and industrial partners as well as external stakeholders seek to jointly create solutions and methodologies for innovative and replicable city development, based on lessons learned and strong knowledge exchange. Therefore the project defrined a complex iterative peer-to-peer process, allowing for a constant knowledge exchange among all affected stakeholders

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Smarter Together: Progressing Smart Data Platforms in Lyon, Munich, and Vienna

In a context where digital giants are increasingly influencing the actions decided by public policies, smart data platforms are a tool for collecting a great deal of information on the territory and a means of producing effective public policies to meet contemporary challenges, improve the quality of the city, and create new services. Within the framework of the Smarter Together project, the cities of Lyon (France), Munich (Germany), and Vienna (Austria) have integrated this tool into their city’s metabolism and use it at different scales. Nevertheless, the principle remains the same: the collection (or even dissemination) of internal and external data to the administration will enable the communities, companies, not-for-profit organizations, and civic administrations to “measure” the city and identify areas for improvement in the territory. Furthermore, through open data logics, public authorities can encourage external partners to become actors in territorial action by using findings from the data to produce services that will contribute to the development of the territory and increase the quality of the city and its infrastructure. Nevertheless, based on data that is relatively complex to extract and process, public data platforms raise many legal, technical, economic, and social issues. The cities either avoided collecting personal data or when dealing with sensitive data, use anonymized aggregated data. Cocreation activities with municipal, commercial, civil society stakeholders, and citizens adopted the strategies and tools of the intelligent data platforms to develop new urban mobility and government informational services for both citizens and public authorities. The data platforms are evolving for transparent alignment with 2030 climate-neutrality objectives while municipalities strive for greater agility to respond to disruptive events like the COVID-19 pandemic.107525EU Horizon 2020 Smart Cities and CommunitiesEU COST Action RESTOR

The Hot and Energetic Universe: A White Paper presenting the science theme motivating the Athena+ mission

This White Paper, submitted to the recent ESA call for science themes to define its future large missions, advocates the need for a transformational leap in our understanding of two key questions in astrophysics: 1) How does ordinary matter assemble into the large scale structures that we see today? 2) How do black holes grow and shape the Universe? Hot gas in clusters, groups and the intergalactic medium dominates the baryonic content of the local Universe. To understand the astrophysical processes responsible for the formation and assembly of these large structures, it is necessary to measure their physical properties and evolution. This requires spatially resolved X-ray spectroscopy with a factor 10 increase in both telescope throughput and spatial resolving power compared to currently planned facilities. Feedback from supermassive black holes is an essential ingredient in this process and in most galaxy evolution models, but it is not well understood. X-ray observations can uniquely reveal the mechanisms launching winds close to black holes and determine the coupling of the energy and matter flows on larger scales. Due to the effects of feedback, a complete understanding of galaxy evolution requires knowledge of the obscured growth of supermassive black holes through cosmic time, out to the redshifts where the first galaxies form. X-ray emission is the most reliable way to reveal accreting black holes, but deep survey speed must improve by a factor ~100 over current facilities to perform a full census into the early Universe. The Advanced Telescope for High Energy Astrophysics (Athena+) mission provides the necessary performance (e.g. angular resolution, spectral resolution, survey grasp) to address these questions and revolutionize our understanding of the Hot and Energetic Universe. These capabilities will also provide a powerful observatory to be used in all areas of astrophysics